specific target organ toxicity, single and repeated exposure, categories 1 and 2.specific target organ toxicity, single exposure category 3 (narcotic effects) and.specific target organ toxicity, single exposure category 3 (respiratory tract irritation).However, this additivity principle does not apply to non-additive hazard classes and categories. Rule 2: If a mixture contains two or more ingredients with the same or similar hazards, the concentration of the hazardous ingredients shall be added first.Rule 1: Test data always takes precedence over cut-off value/concentration limit.There are some special considerations when using cut-off value and concentration limit to classify a mixture: Special Considerations When Using GHS Cut-off Value and GHS Concentration Limit Specific concentration limit: a concentration limit that is specific to a substance and takes precedence over generic concentration limit or cut-off value.Concentration limit: minimum concentration for a substance to trigger the classification of a mixture for a specific hazard class.Cut-off value: minimum concentration for a substance to be taken into account for classification purposes(do not necessarily trigger classification).In addition to that, Europe has set specific concentration limits for specific substances. It shall be noted that the EU CLP regulation has given different definitions to cut-off value and concentration limit. In UN GHS, the cut-off value and concentration limit are equivalent and meant to be used interchangeably. If a mixture contains a hazardous ingredient that has been classified as skin corrosive category 1, the mixture itself will also be classified as skin corrosive category 1 if the concentration of ingredient exceeds 5%. The table below is an example of cut-off value/concentration limit for hazard class skin corrosion/irritation. They are mainly expressed as % thresholds and are primarily used for mixture classification under GHS.
GHS cut-off value or GHS concentration limit is the minimum concentration for a hazardous substance to trigger the classification of a mixture containing it. GHS Cut-off Value and GHS Concentration Limit
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